Page 346 - Color Atlas of Biochemistry

Muscle 337

A. Energy metabolism in the white and red muscle fibers

White (slow) fibers, anaerobic Red (fast) fibers, aerobic

Creatine
Glycogen ADP ADP Myoglobin Fatty acids
phosphate
2+
Glucose Glucose β-Oxidation
Creatine O 2
NAD +
Ketone
N A bodies
A ATP H 2 O 2+
PP P
Cori cycle
(liver) Glycolysis Contraction Acetyl CoA

NADH + H + O 2
ADP
N A
A
P P Respiratory
chain
Lactate Pyruvate N A Tricarboxylic
acid cycle
1
NADH + H +
Adenylate kinase
1
2.7.4.3 A 2 I
P P
2 AMP deaminase CO 2
3.5.4.6 AMP NH 3 IMP CO 2

B. Creatine metabolism
Muscle
S-adenosyl
homocysteine
Liver A A
PP P P P
S-adenosyl NH 2
methionine
H C C
3
N NH 2
4 H 2 C C O 5 O
O P OH
O
HN
Creatine
H 3 C C
Guanidino Creatine N NH
acetate Creatine Creatine phosphate H 2 C O
C

Blood 6 6 O

Creatinine
Glycine
Guanidino- 3 amidinotransferase
acetate 2.1.4.1
Orn H 3 C NH 2
N C Guanidinoacetate
NH 2
3 4 methyltransferase
H C H 2 C N 2.1.1.2
N NH 2 Arg C
H C O O 5 Creatine
2
kinase 2.7.3.2
C Glycine
Not-
O 6
Kidney enzymatic
Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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