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          Fig. 3 Sensory substitution system scheme.


          nearly natural feedback and the possibility to combine with techniques of
          targeted muscle reinnervation.


          4.5.1 Sensory substitution feedback
          Vibrotactile
          Vibrotactile stimulation is evoked by mechanical vibration on the human
          skin at frequencies ranging between 10 and 500Hz. The two main features
          of the stimulus are vibration amplitude and frequency, but other features like
          pulse duration, shape, and duty cycle can be modulated to convey different
          kinds of information (Thomas et al., 2019; Di Luzio et al., 2020). The ampli-
          tude discrimination threshold depends on several parameters, including the
          frequency and location on the body. Lower thresholds are found on glabrous
          skin as compared with hairy skin at frequencies in the range of 150–300Hz
          (Antfolk et al., 2013). Antfolk et al. (2012) assessed the ability of trans-radial
          amputees to discriminate multi-site tactile stimuli in sensory discrimination
          tasks. The study compared different sensory feedback modalities, such as
          vibrotactile and mechanotactile stimuli (pressure or tangential forces on
          the skin, using an artificial hand prosthesis. The results demonstrated that
          pressure stimulation surpassed vibrotactile stimulation in multi-site sensory
          feedback discrimination.
             Thomas et al. (2019) reported a comparison of the feedback intrinsically
          presented in body-powered prostheses (joint-torque feedback) to a com-
          monly proposed modality feedback for myoelectric prostheses (vibrotactile
          feedback). His results suggested that even when haptic feedback was not a
          modality matched to the task, such as the case of vibrotactile feedback,
          performance with a myoelectric prosthesis can improve significantly.
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