Page 444 - Elements of Chemical Reaction Engineering Ebook

Chap. 7 Questions and Problems 41 5
the rate law is

(c) In noncompetitive inhibition, the inhibitor adsorbs itself to a different type
of site than the substrate to render the enzyme-substrate complex inactive.
Assuming that all concentrations of a species can be expressed by their
equilibrium concentrations, show that for noncompetitive inhibition

1
P+E
the rate law is

(d) Sketch three different inhibitions on a Lineweaver-Burk plot.
W-13B It has been observed that substrate inhibition occurs in the following enzy-
matic reaction:
E+S <I
E*S
E.S P+E

E*S+S S*E.S
(a) Show that the rate law for the sequence above is consistent with the plot
in Figure P7-13 of -r, (mmol/L.min) versus the substrate concentration
S (mmoi/L). (Refer to Problem P7-12.)

o 4 o 12 16 20 24 26 32 36 40 44 40 52
S (rnrnol/litsr)
Figure W-13