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Lower-Limb Prosthetics                                       267


              combined with pain at loading” meaning that the survival of the fixture
              could be predicted by bone resorption with an X-ray (Lenneras et al., 2017).
                 All the potential benefits of osseointegration do not come with issues and
              problems to solve. The biggest problem of this technique is its long-lasting
              battle with bacteria at the skin interface and its unknown long-term impact
              on the quality of the bone fixture (Lenneras et al., 2017). Therefore, long-
              term studies are needed. Radiologically found endosteal bone resorption
              accompanied with pain at loading might be associated with potential weak-
              ness of the bone fixture (Lenneras et al., 2017). Different osseointegration
              research groups are taking engineering variants of the implant designs and
              materials in order to achieve a stable mechanical interface between the bone
              and the implant.


              6.2 Inexpensive/Easy and Automated Fabrication
              Effective prosthetic feet can be easily and cheaply fabricated as shown by
              Adamczyk et al. (2006), Adamczyk and Kuo (2013), Hansen and
              Childress (2000), and Sam et al. (2000, 2004). The key is to know the exis-
              ting science behind the design of prosthetic feet as dictated by the rollover
              theory of walking (see Section 4) and use inexpensive fabrication methods
              and materials for the developing countries. This led to the design of the
              NUPRL foot. Another modular inexpensively fabricated leg that was
              intended for the developing countries was the Center of International
              Rehabilitation (CIR) leg.
                 The CAD/CAM has been around for at least three decades for prosthet-
              ics. Its biggest value is that a scan of the residual limb can be taken by dif-
              ferent technologies (e.g., laser), then the CAD model of the personalized and
              pressure-relieved socket can be generated by the CAD software, and finally
              the socket is fabricated in minutes by the CAM techniques. Commercially
              available solutions exist in the market (CAD/CAM SYSTEMS, 2018).

              6.3 Targeted Muscle Reinnervation

              The targeted muscle reinnervation (TMR) has also been performed for per-
              sons with transfemoral amputations (Kuiken et al., 2017a). As reported by
              Hargrove et al. (2013), a TMR procedure was performed on a 31-year
              old during knee disarticulation amputation due to a motorcycle accident.
              The nerve transfer is shown in Fig. 19. The sciatic nerve was split into its
              tibial and common peroneal branches. The tibial nerve branch was sewn
              over the motor area of the semitendinosus, and the peroneal nerve branch
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