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272   Chapter 10 Deep neural network in medical image processing




                                       Kazuyoshi Itoh [8] trained a neural network to identify 12 digits
                                    (10 Arabic and 2 Roman) in an X-ray film using 22 sheets of film as
                                    training data. Similar work in generic object recognition was also
                                    done by Zuo Bai et al. [9] using powerful CNNs. In this chapter,
                                    they proposed an extreme learning machine based on local recep-
                                    tive field. CNNs were used very effectively by Joly et al.[10] for
                                    identifying plants using a huge data set of dated and geotagged
                                    plant photos. Lo et al. [3] used CNN for pattern recognition in
                                    general medical image, which worked in conjunction with
                                    enhanced training methods.
                                       Murat et al. [11] published a comprehensive review of various
                                    applications of deep learning techniques for ECG signal analysis.
                                    Hao et al. [12] published a detailed survey on application of
                                    deep learning algorithms for semantic segmentation; the paper
                                    also discusses the various challenges involving the field. Another
                                    full-blown use of deep learning techniques in the field of detecting
                                    myocardial infarction and arrhythmia is discussed by Gopika et al.
                                    [13]. An important turning point came in the field of image
                                    processing when Navab et al. [14] proposed U-Net, a deep convo-
                                    lutional networkebased framework, which made better use of
                                    annotated transmitted light microscopy images. A highly effective
                                    22-layer deep CNN named GoogLeNet was presented in Large-
                                    Scale Visual Recognition Challenge 2014 by Szegedy et al. [15].
                                    LeCun et al. [16] review the usage of various deep learning models
                                    in the field of processing image, video, and speech; they also high-
                                    light the benefit of using backpropagation algorithm.
                                       Zhao et al. [17] implemented an innovative brain tumor seg-
                                    mentation method by successfully integrating full-fledged CNNs
                                    and conditional random fields, which produced segmentation
                                    results with spatial and appearance consistency. One more inter-
                                    esting research work was carried out by Zhang et al. [18]; they pro-
                                    pose an innovative method of boundary detection by combining
                                    machine learning methods and texture suppression in a unified
                                    framework. Havaei et al. [19] propose a novel method of identi-
                                    fying low- and high-grade glioblastomas from MRI images using
                                    an approach, which uses both local and global features in a
                                    CNN. A dual-staged deep learning framework was proposed by
                                    Bria et al. [20] to train model for detecting small lesion in medical
                                    images, which counters the problem of high class imbalance. Saba
                                    et al. [21] discuss various deep learningebased algorithms to
                                    analyze medical images as well as point out future growth areas
                                    in the field.
                                       Liu et al. [22] discuss the potential of various representative
                                    deep learning models for lung cancer localization and subsequent
                                    diagnosis. Sengupta et al. [23] presented a comprehensive review
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