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                                         Part I: Data Analysis and Model-Building Basics
                                                    Interaction effects come up when you have a model that includes two or
                                                    more variables, and you’re using those variables to explain differences or to
                                                    make comparisons regarding some outcome. When you have two or more
                                                    variables in a model, you can’t automatically study the effect of each variable
                                                    separately; you also have to take into account the way those variables inter-
                                                    act in terms of the outcome. In other words, you have to examine whether or
                                                    not an interaction effect is present.
                                                    For example, suppose medical researchers are studying a new drug for
                                                    depression and want to know how this drug affects the change in blood pres-
                                                    sure for a low dose versus a high dose of the drug. They also compare the
                                                    effects for children versus adults. In total, the model being studied has one
                                                    response variable, an increase in blood pressure, and two factors that may
                                                    possibly explain changes in the outcome, namely age group (adults versus
                                                    children) and dosage level (low versus high). It could be that dosage level
                                                    affects the blood pressure of adults differently than the blood pressure of
                                                    children. This type of model is called a two-way ANOVA model, with a possible
                                                    interaction effect between the two factors (age group and dosage level). See
                                                    Chapter 11 for more.
                                                    One of the first things statisticians do when they have a two-way ANOVA is to
                                                    plot the mean outcomes for each group they’re comparing and look for pat-
                                                    terns. This is called an interaction plot. One interaction plot for the drug-
                                                    study scenario is in Figure 1-3.
                                                                                           Children
                                                     Mean increase
                                           Figure 1-3:  in blood pressure
                                           Interaction
                                            between
                                           age group                                       Adults
                                          and dosage
                                           level when
                                          studying the
                                            effect on
                                              blood               Low                     High
                                            pressure.
                                                                         Dosage Level
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