Page 271 - Multidimensional Chromatography

266 Multidimensional Chromatography

Figure 11.5 Chromatograms of plasma samples obtained with fully automated on-line
SPE–LC: (a) drug-free human plasma; (b) human plasma spiked with omeprazole (100
ng/ml) and phenacetin (internal standard; 1000 ng/ml). Reprinted from Journal of
Pharmaceutical and Biomedical Analysis, 21, G. Garcia-Encina et al., ‘Validation of an auto-
mated liquid chromatographic method for omeprazole in human plasma using on-line solid-
phase extraction,’ pp. 371–382, copyright 1999, with permission from Elsevier Science.