Page 308 - Multidimensional Chromatography

Biomedical and Pharmaceutical Applications 303

Table 11.1 Biomedical applications of on-line heart-cut LC–LC

Sample First
Subsequent
Analyte(s) Sample matrix preparation a LC mode b
LC mode(s) b Detection c Reference
Drugs and Related Compounds
Ampicillin human plasma deproteination C18
C18 post-Flu 28
human urine buffer dilution C18
C18 post-Flu 28
-agonists human/bovine urine none C18
C18 UV 22
bovine urine none C18
C18 MS–MS 23
Basic drugs human serum liq–liq ion-pair
C18 UV 37
extraction C18

Bupivacaine human plasma ultrafiltration C8
CIEX UV 24
Chloramphenicol pig tissue liq–liq PRP
C18 UV 32
extraction

Dexamethasone bovine tissue liq–liq phenyl
silica; CN UV 29
extraction
Dopa and its human/rat plasma deproteination CIEX
C18 EC 66
metabolite

Efletirizine human plasma SPE C18
C18 UV 69
human urine dilution C18
C18 UV 69
Glycyrrhizin and its human plasma SPE C18
C18 UV 39
metabolite
Ibuprofen human serum liq–liq ion-pair
C18; C18 UV 34
extraction C18

Manidipine and its human serum liq–liq ion-pair
C18 UV 38
metabolite extraction C18

Mefenamic acid human serum liq–liq C18