Page 138 - Bio Engineering Approaches to Cancer Diagnosis and Treatment

136 CHAPTER 6 Laser-assisted cancer treatment

Table 6.1 PPT application of gold nanostructures in NIR region.
Type Targeting agent Results Ref
GNS Biological: PEG (1) Colloidal stability and blood [11]
Physical: MRI circulation time increased due to the
presence of PEG molecules
(2) Irreversible tissue damage after
4–6 min of laser irradiation
(3) Tumor shrinkage
Biological: anti-Her2 (1) Dual imaging and therapy properties [12]
antibody conjugated achieved by controlling scattering
PEG and absorption features of the GNSs
(2) Selective destruction of carcinoma
cells due to the presence of Her2
antibody
Biological: anti-Her2 (1) Selective tumor cell damage [13]
nanobody and PEG occurred in in vivo cell culture
medium
Cystine conjugated A54 (1) good targeting ability [14]
peptides (2) low cytotoxicity to healthy cells
Physical: (1) Both superparamagnetic and optical [15]
superparamagnetic iron properties in one platform which lead
oxide to the ability of dual imaging and
Biological: C225 therapy
antibody, PEG (2) Selective targeting to cancerous
cells compared with nan-targeted
nanoparticles in in vivo model
(3) Selective PTT treatment
GNR Anti-EGFR antibodies, (1) Selectively targeted cell lines with [16]
poly(sodium-p- overexpressed EGFRs
styrenesulfonate) (2) Malignance cells destroyed in half
of the power densities needed to kill
normal cells
PEG (1) Targeted photothermal destruction in [17]
in vivo model
(2) Dramatic tumor volume reduction
CD11b antibodies (1) Efficient and selective cell death in in [18]
vitro model
Anti-Toxoplasma gondii (1) Efficiently targeted and kill parasitic [19]
antibodies protozoans
PEG (1) Administrating of X-ray scattering [20]
properties of GNRs to guide X-ray
scattering photothermal agent to
desire side
(2) Increase the PPT efficiency
Anti-EGFR antibodies, (1) Polydopamin improve the GNRs [21]
polydopamin modification