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9.2 Enzyme-Catalyzed Stereoselective Reactions in Continuous-Flow Systems 209

Reference [90] [91] [92] [93] [94]

catalyzed hydrolysis (ranges between brackets indicate the interval of an

E — 13 13 (1–13) 21 (4.2–21) 53 (25–53)

ee (%) >99 85 90 (10–90) 91 (63–91) >90 (88.5–93.3)

40 (7–40) 25 25 (0–25) 0.3–3.9 30 (3.7–42.5)
(%)
c

v (ml min −1 ) 1.1 (0.1–1.1) 80 100 (80–250) 330 0.017

p (bar) 1 4 4 1 1

lipase (CrL) ( ◦ C) T 30 40 40 (30–45) 30 30

Continuous-flow kinetic resolutions by Candida rugosa
Buffer (citrate/phosphate) Isooctane/buffer (phosphate) Isooctane/buffer (phosphate) Isooctane/buffer (phosphate) Isooctane/buffer (phosphate)

Medium

fiber MBR fiber MBR fiber MBR Two-phase CSTR

investigated property). Reactor Product PBR (S)-13 Hollow (S)-14 Hollow (S)-14 Hollow (S)-15 (S)-15

Table 9.4 Entry 1 2 3 4 5