Page 230 - Chiral Separation Techniques

208 8 Nonchromatographic Solid-Phase Purification of Enantiomers

Table 8-1. Enantiomeric purity obtained as a function of α values 6 4 and separation stages for
nonchromatographic systems.
α Number of stages Purity obtained ( %)
4 1 80
4 2 94.1
4 3 98.5
6 1 85.7
6 2 97.3
6 3 99.5
8 1 88.9
8 2 98.5
8 3 99.8
10 1 90.9
10 2 99.0
20 1 95.2
20 2 99.8

illustrated in Fig. 8-3. The two different ChiraLig™ resin particles (enantiomers of
each other) are assumed in this case to have an alpha value of four for each of the R
and S enantiomers in a pair.

Fig. 8-3. Enantio- and chemopurification process using ChiraLig™ with α values of 4.

The separations process is described as follows. A racemic mixture is fed into the
ChiraLig™ system. This feed stream is first passed through the ChiraLig™-S-1 col-