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268 10 The Use of SMB for the Manufacture of Enantiopure Drug Substances: From …
Two different feed concentrations or streams are possible to illustrate this exam-
ple:
Feed stream a: contains a total concentration of 1 g L –1
Feed stream b: contains a total concentration of 10 g L –1
The issue is to design an industrial SMB system capable of processing these two
feed streams, and to compare them in order to select the most adapted solution. The
working pressure should not exceed 10 bar.
10.4.1.1 Gathering Physico-Chemical Parameters
Figure 10.5 shows two analytical injections of a racemic mixture on an analytical
–1
–1
column (V = 4.15 mL (i.e. 250 × 4.6 mm); Q = 1 mL min and 2 mL min ).
Q = 1 mL min –1
Q = 2 mL min –1
Figure 10.5. Chromatograms obtained from an analytical injection.
