Page 356 - Color Atlas of Biochemistry

Connective tissue 347

A. Extracellular matrix

Cell membrane

Collagens Adhesive
(at least proteins:
19 different Elastin, laminin,
types) fibronectin

Cell surface Proteoglycans
receptors and
(Integrins) hyaluronic acid

B. Fibronectins

Heparan sulfate
Fibrin Collagens Integrins Heparane sulfate Fibrin
Domains
N C
ss
ss
N C

–Arg–Gly–Asp–Ser–
Peptide modules Variable peptides
C. Proteoglycans

COO CH 2 OH Disaccharide units
100 nm H O H O
O H O – Uronic acid – Amino sugar –
OH H H H CH 2 OH
O 3 S
H HO H H O O O
COO
H OH H HN C CH 3 OH H O H H O Dermatan
Hyaluronate O H H H sulfate
H OH H HN C CH 3
IduUA GalNAc O
Core protein
COO H 2 C O SO 3
Glycosamino- H O H H O H
glycans
OH H OH H Heparin
O O
H O SO 3 H HN SO 3
GlcUA GlcNAc
COO H 2 C O SO 3
HO O H O Keratan
H O OH H O
20 – 40 H H H sulfate
Disaccharide H OH H HN C
units CH 3
GalUA GlcNAc O
IduUA = Iduronate
COO H 2 C O SO 3
GlcUA = Glucuronate H O HO O
O H O Chondroitin
Ribosome GalNAc = N-Acetyl- OH H H
for = galactosamine H H H 6-sulfate
comparison GlcNAc = N-Acetyl- H OH H HN C CH 3
= glucosamine GlcUA GalNAc O

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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