Page 108 - Control Theory in Biomedical Engineering
P. 108
treatment
30
30
With control Without control the chemotherapy
25 25
20
20 and after
Time (days) 15 Time (days)
15 10.
10 (3), before day
10 by
of system
5
5 eradicated
the tumor cells and effector cells population
0
2 1 0
0 1.8 1.6 1.4 1.2 0.8 0.6 0.4 0.2
1.3 1.2 1.1 1 0.9 0.8 0.7 Effector cells, E(t) 0.6 0.5 0.4 0.3 Imunotherapy control, W(t) be can
30 30
Without control
With control
25 25
20 20 cells’ tumor
15 Time (days) 15 Time (days) populations of the
10 10 that shows
5 5 It w(t).
0 0 Numerical simulations of and
300 250 200 150 Tumour cells, T(t) 100 50 0 0.9 0.8 0.7 0.6 0.5 0.4 0.3 Chemotherapy control, V(t) 0.2 0.1 0 v(t)
Fig. 2 controls with
