Page 310 - Glucose Monitoring Devices

Closed-loop glycemic control results 317

(A)
250

(mg/dL) 200

CGM 150
100

50
1 2 3
Time(day)
(B)
250

(mg/dL) 200

CGM 150
100

50
1 2 3
Time(day)
Meanof closed-loopCGM ± Std.dev.of CGM Set-point
Target zone Hypo-/hyperglycemiathreshold
FIGURE 15.4
Closed-loop results in mGIPsim for the CGM values using (A) sAP and (B) mAP.

and mAP systems is presented in Table 15.3. Fig. 15.7 presents a detailed compar-
ison of the sAP and mAP during the one-hour exercise period and subsequent two-
hour postexercise recovery period for all subjects. The changes in the CGM during
the one-hour exercise session and the two-hour postexercise recovery session are
plotted to show the efficacy of using physiological signals in an mAP system.
No hypoglycemia occurs when the mAP is used, while hypoglycemia (BGC <
70 mg/dL) occurs with the sAP system during the exercise period where the
CGM values drop significantly. The use of physiological variables in the mAP
can benefit AP systems by improving the regulation of the BGC and thus avoid
any potential hypoglycemia. For both the sAP and mAP systems, the CGM measure-
ments never drop below 55 mg/dL or rise higher than 250 mg/dL. Overall, the mAP
performs better than the sAP system across all subjects in regulating glucose concen-
trations within a safe target range while accommodating unannounced disturbances
such as meals and physical activity.