Page 209 - Handbook of Adhesion Promoters
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202                                 Selection of Adhesion Promoters for Different


            9.20 MEDICAL

            Ionomers such as Amplify IO 3701 & 3801 are proposed as adhesion promoters for medi-
            cal applications.
                Hydrophilic adhesion promoters that facilitate intimate binding between metals and
                                             1
            polymers are used in biomedical coatings.  The adhesion promoters based on linear polyg-
                                                1
            lycidol are useful in biomedical applications.  They contain phosphonic acid and acrylate
                  1
            groups.
                Parylene C is biocompatible material and it is frequently used in medical applica-
                2
            tions.  Its poor adhesion in the harsh environments can be improved by a combination of
                                                                  2
            KOH etching and the use of 3-methacryloxypropyltrimethoxysilane.
                Iridium oxide was used as an adhesion promoter between poly(3,4-ethylenedioxythi-
                                                  3
            ophene) and polyimide in medical applications.  Figure 8.6 shows the mechanism of adhe-
                3
            sion.
                The medical devices comprise both polyorganosiloxane and polyphosphazene com-
            pounds which reduce cell encrustation on the device and reduce the severity of thrombosis
            when the devices are in contact with body fluids, and impart anti-rejection properties to
                    4
            the device.
            REFERENCES
            1  Koehler, J; Kuehne, AJC; Piermattei, A; Qiu, J; Keul, HA; Dirks, T; Keul, H; Moeller, M, J. Mater.
               Chem. B, 3, 804-13, 2015.
            2  Charmet, J; Bitterli, J; Sereda, O; Liley, M; Renaud, P; Keppner, H, J. Microelectrochim. Systems, 22, 4,
               855-64, 2013.
            3  Boehler, C; Oberueber, F; Schlabach, S; Stieglitz, T; Asplund, M, ACS Appl. Mater. Interfaces, 9, 189-97,
               2017.
            4  Gordy, T; Ung, N; Fritz, U; Fritz, O; Wojcik, R, US20080095816, Celanova Biosciences, Inc., Apr. 24,
               2008.
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