Page 212 - Handbook of Adhesion Promoters

9.23 Pharmaceutical 205

9.23 PHARMACEUTICAL

The triboelectric charge during pharmaceutical processing can lead to particle surface
1
adhesion. The adhesion and electrostatic charge of the active pharmaceutical ingredients
were significantly reduced when methylcellulose and hydroxypropyl methylcellulose
1
were incorporated. The triboelectric charging showed a linear relationship with the parti-
1
cle surface adhesion.
The adhesion enhancer is a substance which is suitable for fixing pharmaceutical
2
active component in a compacted or compressed form. Addition of the adhesion enhancer
usually leads to an increase in the interparticle surfaces at which bonds can form (e.g., dur-
2
ing the compression procedure). The adhesion enhancers are characterized by increasing
the plasticity of the tableting mixture, resulting in solid tablets being produced by the com-
2
pression. The adhesion enhancer comprises solid, non-polymeric compounds which pref-
2
erably have polar side groups. Examples of these are sugar alcohols or disaccharides. 2
The adhesion enhancer used in this application is a polymer having a glass transition tem-
2
perature in the range of 50 to 100°C.
REFERENCES
1 Ghori, MU; Šupuk, E; Conway, BR, Eur. J. Pharmaceut. Sci., 65, 1-8, 2014.
2 Meergans, D; Stefan, R, US20130224294, Radiopharm GmbH, Aug. 29, 2013.