Page 565 - Handbook of Biomechatronics
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558                                                    Graham Brooker


                                             Aortic
           Arterial         Left-ventricular
           pressure         pressure         pressure       Vascular  Central
                                                            resistance  venous
                                                                    pressure
                   Mitral valve      Aortic valve
                                 Time varying    Arterial
                                 capacitance of  impedance
                                 left ventricle
          Fig. 31 Circuit model for the left ventricle and its load. (Based on Paden, B., Ghosh, J.,
          Antaki, J., 2000. Control system architecture for mechanical cardiac assist devices. In: Pro-
          ceeding 2000 American Control Conference.)



          to blood flow. This open-loop control is adequate over a small operating
          range, but as soon as the patient becomes rehabilitated and starts to resume
          a normal lifestyle, LVADs must be capable of responding to demand.
             Flow rate and differential pressure are key variables needed in the control
          of dynamic blood pumps. However, use of flow and/or pressure probes can
          decrease reliability and increase system power consumption and expense so
          are seldom used. For a given fluid viscosity, the flow state is determined by
          any two of the four pump variables: flow, pressure differential, speed, and
          motor input power. Thus, if viscosity is known or if its influence is suffi-
          ciently small, flow rate and pressure difference can be estimated from the
          motor speed and motor input power (Tanaka et al., 2001).
             Centrifugal pumps provide a linear current (or power) to flow relation-
          ship across a wide range of flow rates. In addition, the characteristic changes
          in current due to pulsatility allow the pump to provide an excellent
          sensorless index of both flow and heart rate. In contrast, axial pumps only
          provide a linear relationship between changes in flow and current over a nar-
          row range of operating conditions and so monitoring current is only indic-
          ative of flow and pulsatility at best. Axial pumps are therefore generally
          operated in a constant speed mode with only suction-detection control algo-
          rithm based on motor current feedback. To overcome this limitation some
          axial pumps now rely a flow probe incorporated into the outlet cannula
          (Moazami et al., 2013).
             As discussed by Paden et al. (2000) and Antaki et al. (2003), any cardiac
          augmentation system must function within the following constraints:
          •  Cardiac output should be above a minimum value. This is nominally
             5L/min, but will vary between 3 and 6L/min depending on the size
             of the patient.
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