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250   Chapter 9 Applications of deep learning in biomedical engineering





















          Figure 9.4 Architecture of CNN. CNN, convolutional neural network. Based on https://commons.wikimedia.org/wiki/File:
          Molumen_zaz_965.svg.


                                    1. It performs the dot product between the filters and the recep-
                                       tive field of input image.
                                    2. The receptive fields are shifted step by step across the width
                                       and height of the input image [7].
                                       To highly reduce the number of hyperparameters, this layer
                                    shares the same parameters in every portion of the image [9].


                                    7. Pooling layer

                                       It performs subsampling or downsampling images by
                                    reducing the dimensionality of the feature maps. It computes
                                    the mean or maximum value of the feature maps. This layer helps
                                    to generate more abstract features.


                                    8. Fully convolutional layer

                                       In this layer, neighboring neurons are connected together to
                                    flatten the matrix. It classifies the features extracted in the previ-
                                    ous layers to produce the final output [7].
                                       The most popular CNNs used in the machine learning appli-
                                    cations are AlexNet, U-Net, and GoogleNet [2].

                                    9. Applications of convolutional neural

                                        network in biomedicine
                                       CNN attains incredible success in various problems such as
                                    image classification and object recognition. In addition, CNN is
                                    the most promising architecture in the biomedical field for auto-
                                    mated disease diagnosis.
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