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254   Chapter 9 Applications of deep learning in biomedical engineering
































          Figure 9.6 Application of GAN in medical images. GAN, Generative Adversarial Network. From https://commons.
          wikimedia.org/wiki/File:Computerized_tomography_of_the_chest_of_a_patient_with_congenital_cystic_adenomatoid_
          malformation.jpg.
                                    • Lesion classification
                                    • Image registration such as prostate MR to transrectal ultra-
                                       sound (TRUS) [13].
                                       The application of GAN in medical images is illustrated in
                                    Fig. 9.6.


                                    14. Deep belief network
                                       DBN is a generative probabilistic model composed of
                                    numerous layers of stochastic and latent variables. These vari-
                                    ables form the restricted Boltzmann machine network in which
                                    each layer communicates with the previous layer.
                                       The first two layers are undirected and accomplish symmetric
                                    connections to create associative memory. The bottom layers
                                    receive connections in a top-down manner. DBN complies with
                                    two-stage training practices:
                                    1. Pretraining stage
                                    2. Fine-tuning stage

                                    15. Pretraining stage

                                       The unsupervised training is executed in the layers one by one
                                    in the upward direction. The main aim of this stage is feature
                                    extraction.
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