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256   Chapter 9 Applications of deep learning in biomedical engineering




                                    18. Biomedical image analysis

                                       The applications of DL in biomedical image analysis are as
                                    follows.


                                    19. Image detection and recognition

                                       Image detection deals with the problem of identifying or
                                    detecting a certain portion/biomarker in a medical image, for
                                    example, organ, region, and landmark localization [4]. A myriad
                                    of DL applications in image detection are as follows:
                                    1. Brain lesion detection in MRI images
                                    2. Automatic lesion detection in fundus images
                                    3. Gastric cancer detection
                                    4. Detection of tumors
                                    5. Detection of dendritic cells
                                    6. Detecting malignant skin cells [16]
                                       Image recognition (or image classification) is the process of
                                    recognizing input images and classifying them in one of the pre-
                                    defined distinct classes. The classifiers may be binary/multiclass.
                                    DL algorithms have the potential to classify the normal and
                                    abnormal images by learning 2D and 3D structure of a body
                                    part. CNN is the prominent neural network architecture, and it
                                    is compatible to perform classification. One instant application
                                    of DL is classifying the images as benign, malignant, or nonneo-
                                    plastic lesions. The main difficulty of deep learning in medical
                                    image classification is the shortage of hand-featured samples [16].


                                    20. Image acquisition and image
                                        interpretation

                                       In bio and medical imaging, the accurate of the diagnosis and/
                                    or assessment of a disease depends on both image acquisition
                                    and image interpretation. Large medical high-resolution imaging
                                    acquisition systems are available, such as parallel MRI, multislice
                                    CT, US transducer technology, digital PET, or 2D/3D X-ray [17].
                                    These medical images contain a multitude of data, which are
                                    conflict in between interpreters. The main part of the DL applica-
                                    tions in bio and medical imaging concerns the computer-aided
                                    interpretations and analyses, for example, analyzing histopathol-
                                    ogy images for breast cancer diagnosis or analyzing the patholog-
                                    ical images with a focus on research and biomarker discovery [18].
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