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236              Chapter 4                                              Vector Spaces

                                    4.6.6. After studying a certain type of cancer, a researcher hypothesizes that
                                           in the short run the number (y) of malignant cells in a particular tissue
                                           grows exponentially with time (t). That is, y = α 0 e α 1 t . Determine least
                                           squares estimates for the parameters α 0 and α 1 from the researcher’s
                                           observed data given below.
                                                             t (days)  1  2   3  4   5

                                                             y (cells)  16  27  45  74  122
                                           Hint: What common transformation converts an exponential function
                                           into a linear function?

                                    4.6.7. Using least squares techniques, fit the following data

                                                  x   −5  −4  −3  −2  −1   0  1  2   3  4  5

                                                  y     2   7   9  12  13  14  14  13  108  4
                                           with a line y = α 0 + α 1 x and then fit the data with a quadratic y =
                                                        2
                                           α 0 +α 1 x+α 2 x . Determine which of these two curves best fits the data
                                           by computing the sum of the squares of the errors in each case.

                                    4.6.8. Consider the time (T) it takes for a runner to complete a marathon (26
                                           miles and 385 yards). Many factors such as height, weight, age, previous
                                           training, etc. can influence an athlete’s performance, but experience has
                                           shown that the following three factors are particularly important:
                                                                               height (in.)
                                                         x 1 = Ponderal index =            ,
                                                                                          1
                                                                             [weight (lbs.)]  3
                                                         x 2 = Miles run the previous 8 weeks,
                                                         x 3 = Age (years).
                                           A linear model hypothesizes that the time T (in minutes) is given by
                                           T = α 0 + α 1 x 1 + α 2 x 2 + α 3 x 3 + ε, where ε is a random function
                                           accounting for all other factors and whose mean value is assumed to
                                           be zero. On the basis of the five observations given below, estimate the
                                           expected marathon time for a 43-year-old runner of height 74 in., weight
                                           180 lbs., who has run 450 miles during the previous eight weeks.
                                                                 T    x 1    x 2  x 3
                                                                181   13.1  619   23
                                                                193   13.5  803   42
                                                                212   13.8  207   31
                                                                221   13.1  409   38
                                                                248   12.5  482   45
                                           What is your personal predicted mean marathon time?
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