Page 472 - Book Hosokawa Nanoparticle Technology Handbook

APPLICATIONS
Ichikawa et al. [28, 29]
Kawashima et al. [33]
Kawashima et al. [32]
Takeuchi et al. [18]
Iwanaga et al. [17]
Sakuma et al. [30]
Y oo and Park [34]
Mesiha et al. [49]
Damge et al. [19]
Donini et al. [22]
Das and Lin [20]
Carino et al. [31]
Zhang et al. [15]
Attivi et al. [35]
Lugo et al. [26]
Foss et al. [50]
Li et al. [48]
Vancomycin, bovine
Salmon calcitonin
Salmon calcitonin
Salmon calcitonin
Procine insulin
Human insulin
Human insulin
Bovine insulin
Bovine insulin
Bovine insulin
Elcatonin
Elcatonin
insulin
Dalargin
Insulin
Insulin
rhEGF
TRH
Chitosan, poly(acrylic acid)
Tween-80 and PEG20000
Cetyl-mucin, DSPE-PEG
WGA, TL, or UEA1-N-
Glut-PE conjugates
Polycationic polymer
Chitosan or Carbopol
Pluronic acid
Miglyol core
Pluronic F68
FAO/Fe3O4
Trehalose
None
None
None
None
None
None
348, 453, 479 nm
Characteristics of representative nanoparticulate carriers for oral peptide delivery.
Particle size References Peptide drug Surface-modifying agents or additives Kisel et al. [47] Porcine insulin None 50–250 nm Takeuchi et al. [12] Elcatonin Chitosan 470, 660, 4100 nm 6 DESIGN OF NANOPARTICLES FOR ORAL DELIVERY OF PEPTIDE DRUGS (Eudragit RS)
1 m (80%)
400–1250 nm
200–1200 nm
171–315 nm
170–350 nm
230–340 nm
190 nm
350 nm
220 nm
306 nm
300 nm
100 nm
250 nm
240 nm
85 nm
N/A

Preparation method Thin-layer hydration/ ultrasonication Thin-layer hydration/ ultrasonication Reverse evaporation Thin-layer hydration Thin-layer hydration Thin-layer hydration Interfacial emulsion polymerization In situ ionic polymerization Ionic polymerization Dispersion polymerization Dispersion polymerization Dispersion polymerization Dispersion polymerization Dispersion polymerization Emulsion-solvent diffusion Emulsion-solvent diffusion Phase inversion Solvent diffusion Multiple emulsion evaporation
Carrier type and base materials Phosphatidylethanol based lipids DPPC/DCP or SA DPPC/Chol/DOPE-PEG Poly(alkyl(meth)acrylates) P(NIPAAm)/P(MAA-g-EG) P(St)/hydrophilic polymer chains Polyesters/polyanhydrides
Table 6.1 Liposomes DSPC/DCP/Chol Soyalecithin/Chol DPPC/Chol/SA P(IBCN) P(IBCN) P(IBCN) P(MAA-g-EG) P(MAA-g-EG) P(AA-g-EG) PLGA PLGA PLGA PLGA PCL
446