Page 76 - Book Hosokawa Nanoparticle Technology Handbook

2.1 STRUCTURE CONSTRUCTION AND FUNCTION ADAPTATION OF NANOPARTICLES
Cholesterol-anchored
Covalent bonding
DSPE-anchored
Lipid anchor
PEG-DSPE, PEG-DSPE
Cholesterol-pullulan TM
Folate, PEG spacer
Folate/Thiamine-
Cationic
Brij 78, Tween20, Tween80
Structures of core Bonding to core Surface property and component and shell Disulfide bonding Antibody Phospholipid bilayer (liposome) DSPE-anchored DSPE-PEG/DSPE-PEG- Egg PC liposome Monoclonal antibody/ DSPE-PEG-Transferrin DTPA-chelation, Integrin alphavbeta Liposome DSPE-anchored 3-antagonist, DTPA Hydrophobic anchor PEG Phospholipid monolayer on lipid Conjugated to BSA Five peptides (nuclear BSA (shell) Gold (core) localization signal, etc.) Covalent bonding Peptide/PEG ZnS (shell) CdSe (core) Covalent bonding Hard polymer shell Core-shell of
Matrix of chitosan
Wax matrix with,
Wax matrix
Typical example of nanoparticles for medical or pharmaceutical applications.
SLN
Delivery agent Magnetite Amphotericin B/ doxorubicin 90 Y Hydrophobic chelating agent of gadolinium Gold CdSe–ZnS Orally administered drugs Various drugs Clariscan (superpara-magnetite) Dextran-coated CLIO CLIO Magnetite Dextran-coated CLIO, MION Irinotecan Tamoxifen Doxorubicin/DNA Plasmid DNA (APTmu—Raf) DNA Mycobacterium phlei DNA Gadolinium–DTPA chelate Gadolinium hexanedione Plasmid DNA lipophilized with cationic lipid Hemato-porphyrin

Therapeutic purpose Hyperthermia, cancer diagnosis Passive and active targeting Target radiotherapy Cancer neutron capture therapy Intracellular diagnostics, therapeutic delivery Disease-sensing, drug delivery Controlled release from microcapsules Thermosensitive release from microcapsules MRI, hyperfusion region visualization, angiogenesis Cell-based therapy, cell labeling MRI of apoptosis (phosphatidyl serine recognition) MRI, hyperthermia, magnetic field-assisted radionuclide therapy MRI, detection of gene expression Passive drug-targeting Pas

Table 2.1.1 a b Hollow c d e f g Core–shell h i j k l m Inorganic simple core n o p q r s Organic simple core t u v w

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