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                                            New                        New pressure
                                            pressure
                                        Yield  10                 Yield  10
                                                      Standard                 Standard
                                                      pressure                 pressure

                                           Standard  New             Standard  New
                                              Temperature              Temperature

                                             Yield = 11              Yield = 11
                                                                                12
                                         Pressure  10  7           Pressure  10  7 optional




                                              Temperature              Temperature
                                          One-Factor-at-a Time       Two-level Factorial
                                              Experiment             Design Experiment

                       FIGURE 22.5 Graphical demonstration of why one-factor-at-a-time (OFAT) experiments cannot estimate the two-factor
                       interaction between temperature and pressure that is revealed by the two-level, two-factor design.

                                          (a)   Time        (b)
                                                                              Optional
                                                                            center point
                                                   Pressure

                                                  Temperature
                                           One-factor-at-a time  Two-level, 3-factor
                                           design in 13 runs   design in 8 runs


                                         (c)                 (d)






                                          Box-Behnken design in  Composite two-level, 3-factor
                                          three factors in 13 runs  design in 15 runs

                       FIGURE 22.6 Four possible experimental designs for studying three factors. The worst is (a), the one-factor-at-a-time
                       design (top left). (b) is a two-level, three-factor design in eight runs and can describe a smooth nonplanar surface. The
                       Box-Behnken design (c) and the composite two-level, three-factor design (d) can describe quadratic effects (maxima and
                       minima). The Box-Behnken design uses 12 observations located on the face of the cube plus a center point. The composite
                       design has eight runs located at the corner of the cube, plus six “star” points, plus a center point. The corner and star points
                       are equidistant from the center (i.e., located on a sphere having a diameter equal to the distance from the center to a corner).

                        It is generally true that (1) the factorial design gives better precision than the OFAT design if the
                       factors do act additively; and (2) if the factors do not act additively, the factorial design can detect and
                       estimate interactions that measure the nonadditivity.
                        As the number of  factors increases, the benefits of investigating several  factors simultaneously
                       increases. Figure 22.6 illustrates some designs that could be used to investigate three factors. The one-
                       factor-at-a time design (Figure 22.6a) in 13 runs is the worst. It provides no information about interactions
                       and no information about curvature of the response surface. Designs (b), (c), and (d) do provide estimates
                       © 2002 By CRC Press LLC
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