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Raman Micr oscopy for Biomedical Applications 247

(b)
FIGURE 8.9 (Continued)

in a tree-like, two-dimensional dendrogram in which one axis refers
to the reduction of clusters with increasing number of iterations and
the other axis to the respective spectral distances.
The detoxification of free heme into hemozoin is an important
drug target. The function of antimalarials based on quinoline is
believed to inhibit hemozoin formation and consequently build up
toxic heme. A better understanding of the mechanism of hemozoin
formation and the drug interaction would be extremely valuable for
the design of new drugs to increase efficacy and overcome resistance