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a) Native urine extract THC-COOH-Gluc.
22.2
521->345
9.170

22.2
Rel. ion abundance 21.200 THC-COOH 13.900
345->299
26.8

THC-COOH-D3
26.8
348->302
9.450

20 25 Time (min)
b) After enzymatic hydrolysis
521->345 THC-COOH-Gluc.
22.2

THC-COOH
26.4 28.400
Rel. ion abundance
345->299

THC-COOH-D3
26.4
348->302 8.200

20 25 Time (min)
Figure 2.7 LC/ESI/MS/MS of THC-COOH and THC-COOH-glucuronide
extracted from native urine (a) and after enzymatic hydrolysis. (Reprinted from
Weinmann W., Vogt S., Goerke R., Muller C., and Bromberger A., Simultaneous
determination of THC-COOH and THC-COOH-glucuronide in urine samples by
LC/MS/MS. Forensic Sci. Int. 113, 381, 2000. Copyright 2000, with permission
from Elsevier Science.)
© 2004 by CRC Press LLC