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5.3 Artificial Cascade Reactions Involving P450s  123



























                            H                            O                       O
                       H               CYP11A1
                     H  H                             H                       H
              HO                                               3β-HSD
                                                     H  H                   H  H
                   Ergosta-5-ene-ol          HO                       O
                                                 Pregnenolone            Progesterone
                                       CYP11A1
                            H
                       H
                     H  H
              HO
                   Ergosta-5,22-diene-ol
              Scheme 5.30 CYP11A1-catalyzed conversion of ergosta-5-ene-ol and ergosta-5,22-diene-ol to pregnenolone in recombinant
              yeast. CYP11A1 reaction details described in Section 5.2.1 and Scheme 5.4). Coexpression of 3β-hydroxysteroid dehydroge-
              nase/isomerase (3β-HSD) leads to progesterone formation.
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