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References 125

for example, carboxylic acid functionalities. In future, cascade systems employing
multiple P450s could become attractive as well, because a combination of different
P450s may provide toolboxes for the synthesis of a broad spectrum of various
intermediates.
We anticipate that artificial enzyme cascades involving P450s will develop
into important topics of biocatalysis and synthetic biology. However, substantial
research efforts still need to be undertaken in this area in order to create various
P450 cascade types with the required robustness for industrial application.

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