Page 192 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

168 7 Synergies of Chemistry and Biochemistry for the Production of -Amino Acids

1 10 20 30 40
R
PI
AtBcar MTA G KN LT VN GD LWD S L DM A KIG G AGGNN R RT LTD ED
M
SkNCBAA M SKD VSSTTT TV SA SP D G TLN LPAA AP L S IA SG R LNQ T I L ETG SQF G G V ARWGQ ESH EFGM RR LAG TA LD
DdNCBAA M SK QFE SVQA T LE KY IPAE E L S EVK RIL Y GY NRGHH V KS LP IC QEA
DmNCBAA M SAF E LKN LNDC LE KH L PPD E L K EVK RIL Y GV EE DQT L ELP T S A
HsNCBAA M AGAE WKSLE EC LE KH LP LP D L Q EVK RVL Y GK EL R K L D L P R E A
RnNCBAA M AGP E W Q SLEQC LE KH L PP DD L S QVK RIL Y GK QT RN L D L P R K A
AtNCBAA MISE NG E TSAEGSI C G YD SLH QL LS AN L KPE L Y Q EVN RL L L GR CG RS LEQIV LP E SA
A
SmLcar MAAP G EN R R VN AD R LWD S L M EM A KI GP G VAG GNN R QT LTD D
AtDcar MT RQMIL AV GQ Q GP I A R A ET R EQ V V G RL L
50 60 70 80 90 100 110
IS
AtBcar A EG RSLFKS W C AAG LT G VD R MGT MF A RP EDPDA LP VY G H LD TQPTG G FDG V GL V A GLEV VRS
M
G
E
L
K
G
L
L
SkNCBAA G AM RDWFTN EC E S LG CK VKVD K IGNMF A VYP G KN GG KPTA T S H LD TQP EA G YD GK I G V A GLEV LR T
DdNCBAA L LD ANKNNF E I VASKV E AD PE Q LRKPRI VR L G IIQN S IGAE T AP I QD QY LAIEA KI E MK ID A AG AMG VN
T
I
T
DmNCBAA KD I AE QNGFD I K G YR FT AR EE Q TRK RRIV RV G A I QN S IV IP T AP IE KQ RE A WN KV K MT IK A AA EA GCN
HsNCBAA F EA ASR EDFE L Q GYAF E AA EE QL RRP R IVHV G LV QN R IPPL A N APVAE QVSA LHR RI K AI V V AA M CGVN
E
RnNCBAA LEA ASE RNF EL K G YAF G AA KE Q QRCPQ IVR V G LV QN R IP P T AP VAE Q VSA LHK RI E E I A V AAM CGVN
L
S
E
D
AtNCBAA KAL SSKHDFD L Q A AS SF AD KE Q MRNPR V VRV G L I QN S IA P T AP FSD Q TRG IFDKL KP I I A AG VA GV N
T
L
L
SmLcar GEG RR LFQSW C E E AG L S MG VD K M GTMF LT RP G TDPD A LPVH I G SHLD TQ PTGGKFDG V LG V S GL EAVR T
E
AtDcar D ML TN AASRG V N FIVFP ELAL T TF FPRWHF T D EA ELD S FY E T MPG P V V RPL F T AA ELG GI
E
120 130 140 150 160 170
AtBcar L NDLNI KT KHP IV VT WSNEE GARF A A ML S VF AG I HD LD YAY S RTG D TDG KTY GD E LK RIGW GEL
P
A
N
SkNCBAA F KD N NY VPNYDV CVV V WF NEE GARF ARS CT GSSVWSHDL LE EAY GLM SVGE DKP ESV YD SLK NI GY IG D
S
DdNCBAA V LC LQ E TWHMPF AF C T RE KYPW V EF A SST GQ SIKF I QRMA K N MVI I S P ML E R DD VHA S I HNA
I
T
E A
R Y
Y
K
DmNCBAA I VCTQ E AWTMPF AF C T RE K EPWC EF A E EA E NGPT TKML A E L A A N MVII HS ILE R DMEHG E I WNA
T
T
I
L
T
HsNCBAA I ICF Q E AWTMPF AF C T RE K LPWT EF A ESA ED GPT TR FC Q K A KN HDMV V VSP ILE R D S EHG DV WNA
RnNCBAA I ICFQ E AWNMPF AF C T RE KLPWT EF A ESA ED GLTTRFCQ KA KKHN MV VIL SP ILE R D RD HG GV WNA
T
I
AtNCBAA I LCL QE AWTMPF AF C T RER R WCEF A EP VD GE STK FLQE AKKL YN MV VSP ILE R D ID HG E V WNA
I
T
I
SmLcar M ND LGI K TKHP IV VT N WT NEEGA RF AA M LA SGVF AGVH T LE Y AYA RK D PE G KSF GDE LKR IGWL G D
P
AtDcar FNLGYA ELVV G GVK R R FN TS
180 190 200 210 220 230 240
I Q
N GA
A
T
M A YF
L G
Y
AtBcar EVGA R R H E H EGP I LE AEG K QIGVV TH GQGLW W LEVT TKEAHT G SP MM R V A L A A
E
K N
S
H G
SkNCBAA TP A YE E ID A HF E L H E D E NKAIG VI T G V Q YA N W QKVT V GVG A A T TP WRL RKD AL LMS S
H
I QGP I EL
I R
DdNCBAA VV V N G IG K SR K N H P TGDFN E STYY M S T LGHP VF T IYG KIA IN ICY G
E
E
N NI
G
I R
E
E
S
DmNCBAA VV I N S GRY LG K HR K N H P VGDFN E STYY M G NTGHP VF T EFG KL A VN ICY G
I R
S
Q
HsNCBAA VV I N S GAV LG K TR K N H P VGDFN E STYY M G NLGHP VF T QFG RI A VN ICY G
E
Q
S
E
I R
RnNCBAA VV I N S GLV MG K TR K N H P VGDFN E STYY M G NLGHP VF T QFG RI A VN ICY G
AtNCBAA VI I N N GNI IG K HR K N H P VGDFN E STYY M G D TGHP VF T VFG KI A VN ICY G
E
E
G
I R
T
I QGP I LE AEN K QIGV V TH GQG LW W
T
SmLcar EE V A R K MH A Y F E Y H E LEET L G REA HT G S P MDM RV N A G L AM A
G
D
AtDcar IL V K S GKI V G K YR K I H P H K E EAY YRP FQ H LE KRYF EG LD G F P VY DVDAA KM GF ICN D
M
LG
P
250 260 270 280 290 300 310
V
I
R
D
AtBcar R I LEK QEVA AHQP GAV AGVG QM I FTPNS RNVLP G K VVF TI D LT PSQAK L N MRA FE R EV P VI A
M
E
L
SkNCBAA K MIV A A SE IAQRHN GLF TC GII DAK P YS VNI IPGE VS F T DFR H PSDDV L ATM LK AA A EFD RLI IKN
V
I
DdNCBAA R HHN LN W LA YG L NGA EI VFNPSAT VG ELS EP MW G EAR NA NYF VGS NR V GTE HFP NEF
A MTN
I
A IAN
I
DmNCBAA R HHP QN WMM FG L NGA EI VFNPSAT IG RLS EP L W S EAR NA SYF T VP NR V GTE QFP NEY
A IAN
HsNCBAA R HHP L N WLMY S L NGA EI IFNPSAT IG ALS ES L W P EA R NA HCF T CA NR V GTE HFP NEF
I
I
RnNCBAA R HHP L N WLMY S V NGA EI IFNPSAT IG ELS ES M W P EAR NA HCF T CA NR V GQE HYP NEF
A I AN
I
L
A IAN
I
AtNCBAA R HHP L N WLA F G LNGA EI VFNPSAT VG ELSEP MW P EAR NA SYF V GS NR V GTE VFP NPF
I
P QAN
V
R
SmLcar R ILE MV QTVAM EN QP G AV GG GQM F F S P SN R N V LPGK VV F T DIR SD LDG M RA IE A EAP KIC
V
AtDcar R RW PET WRVM G LKGA EI ICG GYNTP TH NP VPQ HH EHH L LS Q G SY Q N GA W
D LTS
MA
P
320 330 340 350 360 370 380
A
L
AtBcar E E LGVGC I EA IGH DPV T FDPV LVGRV R S A E R GY T HM D I GGHD A C W TA RVAP STM IFCP CV G
F
S
I S A
SkNCBAA D G GALS Y SE TLQV PA V N FH EV CI EC VSR SA AQF K KD Q VR Q IS A S Q TA PHVP TSM I IF PSKD
E
W G GHD C
S
F
A
DdNCBAA T S G NGKP HKD EGH YG S S YF S S PD N CC T PSES RV S DG L NS V L Q QV KDKW NFQMTA R YE
F
I E DLN C
V E DLN C
A
F
DmNCBAA T S GDG NK HKE EGP YG S S YV A A PD G SR T PSL S RD K DG L LV L L R QV KDFW GFR MTQ R VP
A
V K DLN C
HsNCBAA T S GDG KK HQD EGY YG S S YV A A PD S SR T PGLS RS R DG L LA L L QQV NDVW NFK MTGR YE
F
F
V E NLN C
A
RnNCBAA T S GDG KK HHD EGY YG S S YV A A PD G SR T PGLS RN Q DG L LT L L QQI NDFW TFK MTG R LE
F
Q
I D DLN C
AtNCBAA T S GDG KP HND EGH YG S S HF S A P DA SC T PSLS RY K DG L LS M L RQY KDKW GFR MTA R YE
S
SmLcar E R LGV GC IEA VGH DP V T FD P K LV E IV R G AEKL GY S HM N LS A A WAA KVAP TTM IMCP CV G
F
V G GHD C
A
G
P
L
AtDcar S A AAG KV MEE GGM LG H S CI V A PT GEI V ALTT TL E DE V LA L R REL REHI FN FK AH RQ Q
TA DLD C
390 400 410
S
AtBcar GL HNEAEEISP E WA A AG CDV L L HA VLE TA EIV Q
SkNCBAA GLS H NY Y Y SSP EEIENGFKVL LQAII NYDN Y R VIRG H
E
DdNCBAA LYA K FLTD YI NP NY QP NI I KD PSM K
DmNCBAA LYA E SF KKA SEH GFK P QII KET
HsNCBAA MYA R EEAEA VKS NYS P TIV KE
RnNCBAA MYA R EEAEA VKP NYS P NIV KED LV LAP S SG
AtNCBAA VYA D LLA KYIKPD FK PQVV SDP LLH KN S
SmLcar GLS HNEA ED ISR EWAA AGADV LEH A
AtDcar HYG LIAE F