Page 421 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

18.2 SAM-Dependent Methyltransferases 397

H 3 C CH 3
NH 2 NH NH
H 3 C
N N N N
or
N O N O N N
DNA DNA DNA O
H
N
R R′
RNA CH 3 NH 2 NH 2
O Base N
O N DNA-MTase DNA-MTase N
N O N N NH 3−n (CH 3 ) n
O OH Protein Mtase RHN
RNA RNA-MTase DNA DNA O
R′
RNA
O Base Methyl-donor H 3 N
O
O OH Protein Mtase
RNA-MTase NH R
RNA H 2 N
RNA Small molecule MTase H 2 N NH
O Base O O
O O H H
N
N
R' R R′ R R′
O OCH 3
RNA
or
HN
-OCH 3 or -NCH 3 or -SCH 3 or -CCH 3 HN
H 2 N N(CH 3 ) 2
H 3 CHN NHCH 3
Scheme 18.2 Diversity of substrates of SAM-dependent MTs.