Page 423 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

18.2 SAM-Dependent Methyltransferases 399

Nicotinamide, pyridine, drugs, and xenobiotics Catecholamines and catechols Histamine and α-methylhistamine H 2 S, aliphatic, aromatic and heteroaromatic thiols, thiocyanate, and halide ions Saturated, unsaturated, and branched fatty acids Phenols and substituted phenols 24-Methylenecholest-8-en-3-ol Primary, secondary, and tertiary amines Aromatic a

List of selected SAM-dependent methyltransferases acting on small molecules.

Substrates Glycine Noradrenaline and analogs myo-Inositol Isoflavones C3–C5 aldoximes Isoflavones A variety of flavonoids A variety of flavonoids 7OH-Coumarin derivatives

of reaction N-methylation O-methylation N-methylation S-methylation O-methylation N-methylation O-methylation N-methylation O-methylation C-methylation O-methylation N-methylation S-methylation O-methylation O-methylation O-methylation O-methylation C-methylation

Type

EC number 2.1.1.1 2.1.1.6 2.1.1.8 2.1.1.9 2.1.1.15 2.1.1.20 2.1.1.25 2.1.1.28 2.1.1.39 2.1.1.41 2.1.1.46 2.1.1.49 2.1.1.67 2.1.1.91 2.1.1.150 2.1.1.155 2.1.1.232

Nicotinamide N-methyltransferase Catechol O-methyltransferase Histamine N-methyltransferase Thiol S-methyltransferase Fatty-acid O-methyltransferase Glycine N-methyltransferase Phenol O-methyltransferase Phenylethanolamine N-MT Inositol 3-methyltransferase Sterol 24-C-methyltransferase Isoflavone 4 ′ -O-methyltransferase Amine N-methyltransferase Thiopu

Table 18.1 Name Kaempferol