Page 60 - Biodegradable Polyesters

38 2 Functional (Bio)degradable Polyesters by Radical Ring-Opening Polymerization

poly(2-(N-tert-butoxycarbonylamino)ethoxy-2-oxo-1,3,2-dioxaphospholane)
(PEEABoc), dextran, and polycitric acid made by metal-catalyzed ROP reac-
tions [63–65]. A good review article on the subject is Ref. [66]. The radical
copolymerization of CKAs with the appropriate vinyl monomers also provided
degradable polymeric micelles. In one of the studies, MDO was copolymer-
ized with poly(ethylene glycol) methyl ether methacrylate (PEGMA) and
7-(2-methacryloyloxyethoxy)-4-methylcoumarin methacrylate (CMA) to gen-
erate a series of biodegradable, biocompatible, and cross-linkable copolymers
capable of self-assembling into micelles in aqueous solution (Scheme 2.10).
4-Methylcoumarin methacrylate (CMA) provided photo-cross-linkable sites and
the use of the system in delivery of the anticancer drug doxorubicin (DOX) was

O
O O + O + O O x O y O c
O O O
O Biodegradable
O O O
O O m O
m
O Biocompatible O O

Photo cross-linkable

MDO PEGMA CMA P(MDO-co-PEGMA-co-CMA)

Self-assembly

: Doxorubicin (DOX)
Scheme 2.10 Reaction scheme for the formation of degradable, cross-linkable system
capable of self-assembling into micelles in aqueous solution and loading the anticancer
drug doxorubicin (DOX). (Reproduced from Ref. [67].)