Page 18 - Chiral Separation Techniques

Chiral Separation Techniques: A Practical Approach, Second, completely revised and updated edition
Edited by G. Subramanian
Copyright © 2001 Wiley-VCH Verlag GmbH
ISBNs: 3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)
Index

α-value, enantiopurification 204 aprotic solvents 168
acetonitrile 301 aqueous buffers 51
acid/base ratio, enantiomeric separation 46 assisted chiral separations 138 ff
active pharmaceutical ingredients (APIs) 254 ff association constants, monomer–template
additives assemblies 168
– capillary electrophoresis 66 asymmetric synthesis
– chiral drugs 288 – chiral drugs 317
adsorption–desorption kinetics, imprinted chiral – enantiopure drugs 253
phases 165 asynchronic shift, enantiopure drugs 262
adsorption isotherms atropisomer imprinting 170
– enantiopure drugs 259 ff AZT, CHIRBASE 101 f
– imprinted chiral phases 162 ff
affinity, enantiopure drugs 259
agarose gel 290 β-blockers
aglycone basket 26 – enantiopure drugs 257
albuterol – enantiopurification 217
– chiral drugs 288 – enantioseparation 32
– enantiomeric separation 41 – supercritical fluid chromatography 303, 312
alprenolol 7 band broadening, chromatographic 165
amines band dispersion, electrophoresis 295
– enantiopurification 204 ff baseline separation 44
– imprinted chiral phases 156 batch chromatography 255
amino acids batch definition, enantiopure drugs 277
– capillary electrophoresis 63 batch elution modes, chromatography 4
– crystallization 2 batch processes, electrophoresis 289
– derivatization 189 f, 212 bi-naphthol enantiomers 227, 235, 243 f
– enantioselective membranes 15 bi-Langmuir model 162
– enantioseparation 48 bind release separation 206
– imprinted chiral phases 155, 160 binding constants, electrophoresis 293
– selectors 74 f binding sites
aminoglutethimide 9 – imprinted chiral phases 152
aminopropyltriethoxysilane 71, 85 – L-PA 162 f
aminosaccharides 26 – MICSPs 166
ammonia 46 bioanalytical methods, drug guidelines 321
amylose derivatives 303, 309 bioavailabilities, enantiomers 287
analysis biopharmaceutical studies, drug guidelines 330
– drug guidelines 324 bleeding, templates 166
– enantioseparation 44 bovine serum albumin (BSA) 11, 16
analytical separation, amine enantiomers 211 Brönstedt acids 157
anionic cyclodextrin 288 brush type chiral staionary phases 307 f
antibiotics brush type selectors
– chromatography 6, 17 – enantioseparation 59
– supercritical fluid chromatography 303, 309 – imprinted chiral phases 171
antigens, enantiopurification 217 bubble fractionation, imprinted chiral
applications phases 180
– enantiomers 203, 217 buffers 48 ff
– industrial scale 132 building modules, selectors 69
– simulated moving bed 219 ff bulk liquid membranes, 130