Page 23 - Chiral Separation Techniques

348 Index

preferential crystallization 2 recognition mechanism
preparation techniques 1–23 – chiral 26
– cyclodextrins 287–298 – enantiopurification 206, 211
– enantioseparation 55–93, 199 – enantioseparation 55–93
– membranes 134 – imprinted chiral phases 157
– supercritical fluid chromatography 306 – MICSPs 166
pressure, supercritical fluid chromatography – supercritical fluid chromatography 307
300, 312 recycling 4, 8
pressure sensors 260 regulation, chiral drugs 317–341
prilocaine 318 resolution
primaquine enantiomers 303 – capillary electrophoresis 65
process design, enantiopure drugs 267, 275 – enzymatic 3
process flow, enantiopurification 210 ff – racemates 151, 155
profen – supercritical fluid chromatography 304
– enantiopurification 217 resolution factors, molecularly imprinted
– enantioseparation 30, 34 polymers 155
– selectors 83 retention factors 57, 278
proline 10, 16 retention time, imprinted chiral phases 154
propoxyphene 318 reverse osmosis 127
propranolol reversed phases, glycopeptides 38, 48 f, 53
– chromatography 7 ristocetin 26, 36 f
– enantioselective membranes 15
– enantioseparation 47
proteins saccharides 26
– chromatography 4, 10, 16 salbutamol 15
– drug guidelines 319 sales, enantiomers 203
– enantioseparation 58 scale-up procedures 138
purification screening
– enantiomers 203–218 – enantioseparation 61, 68, 74, 78
– enantiopure drugs 255 – molecularly imprinted polymers 176
– simulated moving bed techniques 219–251 selective derivatization 196 ff
purity 324 selectivities
pyridine group 206 – enantiopurification 204
– enantioseparation 40, 60, 76
– imprinted chiral phases 158
quality 324 – membranes 132 ff
quantitative structure-selectivity relationship – selectors 74
(QSAR) 106 – supercritical fluid chromatography 302
selectors
– enantioseparation 56 ff
racemates – glycopeptides 25
– derivatization 186, 198 – imprinted chiral phases 171
– drug guidelines 326, 336 – membranes 129 ff, 139
– enantioseparation 287 sensor systems 136
– imprinted chiral phases 151, 155 separation factors
racemic compounds 29 – enantioseparation 57, 60
racemic switches – racemates/molecularly imprinted
– drug guidelines 339 polymers 155
– enantiopurification 217 separation regions, simulated moving bed
racemization 1 f, 171 231, 239
raffinate purities 260 Separex 257
rational CSP design 199 shrinkage, MICSPs 166
reactive separation, derivatization 200 silica-based CSP 310
reactivities, selectors 71 silica beads 56, 76
receptors, enantiopurification 217 similarity searching, CHIRBASE 101, 113
reciprocal methods, enantioseparation 61 simulated moving bed (SMB) 3, 7 f, 55
reciprocal screening, parallel libraries 78 – derivatization 199