Page 21 - Chiral Separation Techniques

346 Index

ibuprofen library-on-bead, selectors 85
– drug guidelines 319, 339 Licosep 257
– enantioselective membranes 15 life time, membranes 144
– supercritical fluid chromatography 309 ligand exchange, chromatography 4, 16
imino acids 48 ligand–receptor chemistry 169
imprinted chiral phases 151–184 ligands
imprinted polymers, molecular 134 – CHIRBASE 110
impurities, drug guidelines 325, 329, 335 f – enantiopurification 207, 217
in-batch screening 74 linear driving force (LDF) approximation 222
indirect resolutions 3 liquid chromatography (LC) 2, 55
industrial applications – enantiomers 287, 299
– enantiopurification 216 liquid–liquid extractions, membranes 139 f
– membranes 132 liquid–liquid partitioning, imprinted chiral
injections, multiple close 4 phases 151
inorganic conjugates 66 liquid membranes 128 ff, 141
in-situ polymerization 134 liquid–solid partitioning, imprinted chiral
instrumentation, supercritical fluid phases 151
chromatography 302 loadability, enantioselective membranes 14
interactions loading capacity, chromatography 4, 10 f
– CHIRBASE 108 low-selectivity, molecular imprinted chiral
– cyclophanes 66 phases 161
– glycopeptides 28 luminescence 115
– supercritical fluid chromatography 307
interaction sites, templates 173
inversion, membranes 134 machine learning 119
ionizable groups, glycopeptides 26 macrocyclic antibiotics 303, 309
ISIS software 96 macrocyclic glycopeptides 25–54, 58
isobuteryl-L-cysteine (IBLC) 191 ff macroporous beads 78
isoelectric focusing 289 mandelic acid 16
isoleucine 10 mass balance, simulated moving bed 223
isoprenaline 318 mass transfer, MICSPs 166
isotachophoresis 289 mass transfer resistance, simulated moving
isotherms, adsorption 162 f bed 237 ff
McCabe–Thiele model 136
medium-pressure liquid chromatography
Japanese requirements, drug guidelines 331 (MPLC) 4 f
membranes 13 ff, 127–150
mercaptoethanol 193
ketamine 318 Merrifield resins 69, 76
keto-esters 78 metal ion complexes, enantioseparation 59
ketoprofen 42 methacrylic acid (MMA) 153 ff
Knox equation 263 methadone 294
Kozeny–Carman equation 264 methanol 301, 311
kynurenine 11, 16 methionine 48
methylphenidate 44
methylphenobarbitone 320
L-PA (L-phenylalanine anilide) metoprolol 320
154 ff, 160 ff, 165 f micellar enhanced ultrafiltration (MEUF) 145 f
laminar flows 264 microcrystalline cellulose triacetate (CTA) 5 ff
Langmuir isotherms microfiltration 127
– enantiopure drugs 262 mixed libraries, selectors 83
– simulated moving bed 223, 233 mobile phases
Langmuir models, imprinted chiral phases 162 f – glycopeptides 29, 40
large-scale chiral separation 127 ff – imprinted chiral phases 157
LEC, chromatography 6 – supercritical fluids 301
levobupivacaine 339 modeling, simulated moving bed 219–251
levofloxacin 339 modifiers, SFC 311 f