Page 24 - Chiral Separation Techniques

Index 349
– drug guidelines 321 temperature behavior
– enantiopure drugs 253–285 – glycopeptides 44
– imprinted chiral phases 151 – supercritical fluid chromatography 300, 312
– modeling 219–251 template binding 153
single-crystal structures 79 template interaction sites 173
single enantiomers 326 terbutaline 16
site distributions, imprinted chiral phases 162 f terfenadine
solid-phase purification 203–218 – derivatization 196
solid-phase synthesis 71, 74 – enantiopure drugs 253
solid support, enantiopurification 204 tetrahydrofuran (THF) 180
solubility 61 thalidomides 203, 340
solution structures, monomer–templates 161 theonine 49
solvents thermodynamic behavior, imprinted chiral
– enantiopure drugs 255, 276 phases 174
– enantiopurification 210 thin-layer chromatography (TLC) 16, 289
– enantioseparation 61, 74 thiol compounds 191
– imprinted chiral phases 174 thiophenylglycine 49
– monomer–template assemblies 168 thiourea 82
– supercritical fluids 301 threonine
Sorbex flowsheet 221 – crystallization 2
sotalol 46 – enantiopure drugs 257
stability 329 toxicology
stationary phases 55 – drug guidelines 326
– derivatization 186 – enantiopure drugs 253
– glycopeptides 25–54 tramadol 9
see also: chiral stationary phases transfer units, membranes 143
stereochemical purity 324 transport mechanism, membranes 133
stereoisometric drugs 253, 257 trifluoroacetic acid (TFA) 46
stereoselective synthesis 254 tri-Langmuir model 162
stereospecific synthesis 287 tripeptides 71
structural characteristics, glycopeptides 26 f tropicamide enantiomers 308
structure-binding relationships, imprinted chiral true moving bed (TMB) 220 ff, 258
phases 157 TSAR 106
subcritical fluid chromatography 12 f, 299–315 tyrosine 155
substitution pattern, selectors 82
supercritical fluid chromatography (SFC)
12 f, 299–315 ultrafiltration 133, 145 f
supercritical simulated moving bed 260 Ultron ES-OVM 116
supported liquid membranes 130 urea, selectors 82
surface imprinting 134
surfactants 129
suspension polymerization 178 validation
swelling, MICSPs 166 – drug guidelines 324, 337
switch time intervall, true moving bed 236 – enantiopure drugs 277
switches, enantiopure drugs 254 valine 213
synthesis Van Deemter equation 263
– chiral drugs 317, 323 vancomycin
– MICSPs 166 – antibiotics 6
– molecularly imprinted polymers 176 – chromatography 17
– mixed library 58 – enantioseparation 26, 37
– stereospecific 287 – supercritical fluid chromatography 310
system searching, CHIRBASE 101 vancosamine 26
vinylbenzamidines 169
vinylpyridines (VPY) 171
Tanimoto coefficients 113 volume yields, enantiopurification 210
tartaric acid 16
teicoplanin 4 ff, 26, 37 f