Page 20 - Chiral Separation Techniques

Index 345
dihydropyrimidines 78 flow rates
dinitrobenzoyl (DNB) group 73 – enantiopure drugs 270
dipeptides 71 – enantioseparation 40, 44
dipole–dipole interactions 307 – supercritical fluid chromatography 312
dipole–dipole stacking 107 – supercritical fluids 301
disopyramide 319 fluorimetric detection 188
dispersion, enantiopure drugs 263 fluoxetine 49
distillation, enantioselective 17 flurbiprofen 309
distomers, enantiopurification 206 fluvastatin 319
diversity, CHIRBASE 113 foam flotation 17
dosage, fixed-combination 254 formoterol 9
dry phase inversion 134 fractionation
dye labels, selectors 69 – imprinted chiral phases 151, 180
dyssymmetries, enantiopure drugs 260 – liquid membranes 141
free-radical polymerization 153
Freundlich model 163
efficiency functional groups
– enantioseparation 60 – glycopeptides 38
– supercritical fluid chromatography 304 – imprinted chiral phases 157
electro-osmotic flow 295 functionalized beads 72
electrochromatography 60
electrophoresis 60
– preparative techniques 287–298 gas chromatography (GC) 13, 55, 301
ellipticity, selectors 76 gel electrophoresis 16, 289
elution gel matrix 289
– enantiopure drugs 258 glucose-fructose separation 222
– supercritical fluids 301 glutamic acid 2
elution mode, chromatography 4 glycopeptides
elution profiles, imprinted chiral phases 164 – enantioseparation 58
emulsion liquid membranes 129 f – macrocyclic 25–54
enantiomeric separations guafanesin 9
– glycopeptides 25–54
– selectors 57
enantiopure drugs, manufacture 253–285 heat dissipation 294
enantiopurity 187 hetrazepine 257
enantioselective distillation 17 hexapeptides 63
enantioselective synthesis 1 f hexobarbitone 319
enantioselectivity high-feed throughput, enantiopurification 210
– glycopeptides 30 high-pressure liquid chromatography (HPLC) 4
– membranes 13 f, 127, 133, 136 f, 141 – deconvolution 64
enzymatic kinetic resolution 3 – drug guidelines 321
enzymatic reactors 11 – enantiomers 287
enzymes, enantiopurification 217 – imprinted chiral phases 176
ephedrine 158 high selectivity, enantiomer separations 158
epoxide enantiomers 243 hollow-fiber membranes 130, 139
ethoxysilane 71 host–guest chemistry 169
European requirements, chiral drugs 322 host–guest complexes 204
eutomers 206 hydrogen bonding
extraction methods – CHIRBASE 107
– chiral 15 – enantiopurification 206
– membranes 139 ff – imprinted chiral phases 157, 173
– selectors 83
– supercritical fluid chromatography 307
feed stream, enantiopure drugs 268 hydrosylation 83
fexofenadine 253 hydroxyl/halogen carboxylic acids 30, 36
filtration 127
flash chromatography 7