Page 19 - Chiral Separation Techniques

344 Index

bupivacaine 288 – molecularly imprinted polymers 176
bupranolol 15 complementary separations, glycopeptides
30 f, 37
complete library column, selectors 85
capillary electrophoresis (CE) 62, 288, 299, 321 condensation 78
carbamyl phenylalanine 46 conglomerates, crystallization 2
carbon-based chiral stationary phases 310 conjugates, cyclophanes 66
carboxylic acids 156, 168, 173 contaminants, enantiopure drugs 278
carriers, enantiospecific 128, 131 continous flow free electrophoresis 294
carvediol 16 continuous processes, electrophoresis 293 f
cascades, membranes 133, 136 f CORINA 106
cation exchange, cyclophynes 66 co-solutes 2
cationic analytes 288 countercurrent
cellulose carbamate 5 – electrophoresis 288
cellulose derivatives 303 – enantiopure drugs 258
cellulose triacetate (CTA) 257 – membranes 139 f
centrifugal partition chromatography (CPC) 10 – simulated moving bed 221
chemical yields, enantiopurification 210 countercurrent chromatography (CCC) 3, 7 ff
chemopurification, ChiraLig 208 covalent bonds 153
chiral crown ethers 15 covalent derivatization 187
see also: crown ethers crown ethers
chiral drugs, country specific guidelines – chiral 15
317–341 – enantiopurification 206
chiral selectors see: selectors – enantioseparation 59
chiral stationary phases (CSPs) 4, 55 – membranes 131
– derivatization 198 Crownpak CR 114
– enantiomers 287 ff crystallization 2
– enantiopure drugs 253 – fractional 151
– glycopeptides 25–54 current good manufacturing practices (cGMP)
– imprinted 151 f, 165 f compliance 253–285
– receptors 106 cyclic amides 69
– supercritical fluid chromatography 299 ff, cyclic compounds, enantioseparation 58
307 ff cyclocondensation 78
Chiral-AGP 116 cyclodextrins
Chiralcel OD 110, 303, 309 – chromatography 5 ff, 11 ff, 16
Chiralpak AD 114, 306 – electropheresis 287–298
CHIRBASE 95–125 – enantioseparation 59
CHIRSOURCE 111 – membranes 15, 131
chloroquine 288 – supercritical fluid chromatography 303, 308
chlorpheniramine 288 cyclophanes 66
chromatography 2 ff cysteine 192
– enantiopure drugs 254
– imprinted chiral phases 151, 165
circular dichromism Darcy law 264
– drug guidelines 324 database, CHIRBASE 95–125
– selectors 77 decision tree, CHIRBASE 119
clinical studies, drug guidelines 326, 330 deconvolution 62 ff, 85 f
closed-loop recycling with periodic intra-profile derivatization chromatography 5, 8 f, 185–202
injection (CLRPIPI) 8 derivatized polysaccharides 309
closed-loop systems, enantiopure drugs 276 derivatizing agents 2 ff
COLNEW/SYS software 235 desorption kinetics, imprinted chiral phases 165
column coupling detection wavelength, enantioseparation 40
– enantioseparation 30, 39 f dexfenfluramine 339
– supercritical fluid chromatography 305 dexibuprofen 339
combinatorial chemistry dexketoprofen 339
– enantiopurification 217 dichloromethane 301
– enantioseparation 62, 70 dihexyltartrate 15