Page 22 - Chiral Separation Techniques

Index 347
moieties, electrophoresis 290 PDECOL software 227
molecular imprinted polymers (MPIs) peak shaving, chromatography 4, 8
4, 14, 134, 153 Peclet number 225, 244
molecular recognition technology (MRT) 211 peptides
molecular similarity, CHIRBASE 113 – enantiopurification 217
monomer–template assemblies – enantioseparation 48
153 ff, 167 ff, 174 f – imprinted chiral phases 156
monomer–template solution structures 161 performance parameters, true moving bed
monosaccharides 158 235, 247
morphology, imprinted chiral phases 175 f permeability 134, 137
multicomponent condensation 78 pH effects, enantiomeric separation 51
multicomponent mixtures 262 pH zone refining 11
multimodal glycopeptides 28 pharmacokinetic profile, enantiomers 287
multiple-close injections 4 pharmacology
multistage separation 146 – drug guidelines 318, 326
– enantiopure drugs 253
phase inversion, membranes 134
nanofiltration 127 phenoxypropionic acid 7
naphtyl alanine 49 phensuccimide 43
naphtyl group 204 phenylalanine 212
naproxen 37 L-phenylalanine anilide (L-PA)
nitrogen bases 168 154 ff, 160 ff, 165 f
nonchromatographic techniques 203–218 phenylethyl alcohol 257
noncovalent imprinting 178 phenylglycine 155
nonselective membranes 127 phosphine oxides 302, 307
norephedrine ortho-phthaldialdehyde (OPA) 191 ff
– chromatography 10 physical properties, supercritical fluids 300
– enantiopurification 217 physico-chemical parameters, enantiopure
– enantioselective membranes 15 drugs 262, 268
norvaline 37 picenadol 318
NovaSyn TG amino resin 76 pipecolic acids 49
nuclear magnetic resonance (NMR) 321 pipoxeran 292 ff
Pirkle DNPG 114
Pirkle phases
ofloxacin 16 – chromatography 5 f, 12 f
oligopeptides 62 f, 71 – supercritical fluid chromatography 307
one-bead–one selector library 68 f polar organic modes, glycopeptides
operating conditions 28 ff, 38 ff, 46 f
– enantiopure drugs 255 polyacrylamides 5 ff
– SMB/TMB 228, 242, 247 polymer membranes 132 f
optical isomers 257 polymer structures, imprinted chiral phases 175
optical microscopy 68 polymerization techniques 178
optical rotary dispersion 324 polymers
optical yields, enantiopurification 210 – enantioseparation 56 f
organic amines 206 – glycopeptides 25
organic conjugates, cyclophanes 66 – selectors 76
organic modifiers, glycopeptides 38, 48 f, 53 polysaccharides
organic polymer supports 76 – chromatography 5 ff
orthogonal collocation in-finite elements – enantioselective membranes 14
(OCFE) 227 – enantioseparation 58
osmosis, reverse 127 – imprinted chiral phases 151
overall statistics, CHIRBASE 98 – supercritical fluid chromatography 309
oxprenolol 7 polystyrene 69
postcolumn techniques, derivatization 186
prazinquate 257
parallelism advantage, selectors 85 preclinical studies, drug guidelines 326
partitioning, imprinted chiral phases 151 precolumn techniques, derivatization 186