Page 71 - Chiral Separation Techniques
P. 71
2.4 Optimization 47
Fig. 2-12. The effect of the acid/
base ratio on the selectivity of
sotalol on teicoplanin CSP (250 ×
4.6 mm) in the new polar organic
mode. The flow rate was 1.0 mL
min –1 at ambient temperature
(23 °C).
Fig. 2-13. The effect of acid and base concentration on the res-
olution of propranolol on teicoplanin CSP (250 × 4.6 mm) in the
new polar organic mode. The flow rate was 2.0 mL min –1 at
ambient temperature (23 °C).
