Page 292 - Color Atlas of Biochemistry

Blood 283

A. Regulation of O transport
2

1 Bisphosphoglycerate 1.0
mutase 5.4.2.4
1,3-Bisphospho- 2 Bisphosphoglycerate 0.8
glycerate phosphatase3.1.3.13
1
ADP
2,3- 0.6
ATP Bisphospho- 1 2 3 4
3-Phospho- glycerate (BPG) Saturation pH = 7.40
glycerate 2 0.4
O O 1 Myoglobin
C 2 Hemoglobin (Hb)
0.2
P H C O P 3 Hb + BPG
2-Phospho- 4 Hb + CO + BPG
2
glycerate H C O P 0.0
2
0 10 20 30 40 50
O2 partial pressure (mmHg)

1. BPG metabolism 2. Saturation curves

D. Hemoglobin and CO transport
2

CO 2 O 2 CO 2 Lungs O 2

CO 2 O 2
Lungs

CO 2 + H O 1 [H CO ]
2
3
2
HCO 3 HCO 3 + H - Hb Hb -O + [H CO ]
2
3
2
Cl Cl
pO 2
100 mmHg
Blood Erythrocyte

Heart

Cl Cl

HCO 3 HCO 3 + H - Hb Hb - O + [H CO ]
2
3
2
pO 2 CO +
2
3
30-40 mmHg 2 H O 1 [H CO ]
2
CO 2 O 2
Veins Arteries
Tissue
CO 2 O 2
2
1 Carbonate dehydratase [Zn ] 4.2.1.1

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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