Page 296 - Color Atlas of Biochemistry

Blood 287

A. Distribution of iron
Heme enzyme (<1%)
O 2 Myo- Transport and
globin storage forms
(6%) (26%)

Hemo- Iron–sulfur
Oxygenated heme globin clusters Fe4S4-Cluster
(66%) (< 1%)
1. Heme iron 2. Non-heme iron

B. Iron metabolism
120 – 150 mg Free iron

Heme Transferrin
Erythro-
poiesis Ferritin
E.g., Hemosiderin
ascorbate
Bone
Fe 3 + marrow
XH 2 Store
Fe 2 +

X 2500 – 3000 mg
Fe 2 + 30 mg . d -1
1mg . d -1 Fe 2 + Heme Erythro-
cytes
.
1-2 mg d -1
Intestine
Trans-
Ferritin ferrin 4 mg Erythro-
cyte
degra-
. dation
Blood
30 mg d -1
Concentration serum Fe 2 +
of free iron in
the blood
5 mg . d -1 5 mg . d -1
. -1
< 10 -10 mol l
Bilirubin

Spleen
Insoluble

Ferritin Hemosiderin

150 – 200 mg

Apoferritin (section) Storage tissue Lactoferrin
(liver, etc.)

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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