Page 300 - Color Atlas of Biochemistry
P. 300
Blood 291
A. Blood clotting
Kallikrein Intravascular pathway Extravascular pathway
?
~ 3 min ~ 10 s
Endothelium
Deeper
wall
XII XIIa III layers
Function
unclear Thromboplastin
XI XIa
IX IXa VIIa VII
VIII VIIIa + Ca 2 PL
X Xa
V Va + Ca 2 PL
II IIa Thrombin
Fibrinogen Fibrin
I
Prothrombinase complex
Fibrin
polymer
II Thrombin
Xa IIa
XIII XIIIa
K 2
EGF 2
K 1
EGF 1
Va
Gla domain
Ca 2 Ca 2 Ca 2 Ca 2
Thrombocyte Polymeric
membrane fibrin network
Coagulation factors
l Fibrinogen lX Christmas factor* 3.4.21.22
ll Prothrombin* 3.4.21.5 X Stuart–Prower factor* 3.4.21.6
lll Tissue factor/thromboplastin Xl Plasma thromboplastin antecedent* (PTA) 3.4.21.27
lV Ca 2 Xll Hageman factor* 3.4.21.38
V Proaccelerin Xlll Fibrin-stabilizing factor* 2.3.2.13
Vl Synonym for Va
Vll Proconvertin* 3.4.21.21 * Proenzyme
Vlll Antihemophilic factor A Contains γ-carboxyglutamate
Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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