Page 294 - Color Atlas of Biochemistry

Blood 285

A. Reactive oxygen species B. Biological antioxidants

Quinols α-Tocopherol (vitamin E)
Molecular O
oxygen 2 and enols Ubiquinol (coenzyme Q)
Ascorbic acid (vitamin C)
e Carotenoids β-Carotin
a
Dispro- Lycopin
portionation
Others Glutathione
Bilirubin
Superoxide 1
radical O 2 1. Examples

e Glu Cys Gly
b
H O H O
Hydrogen
peroxide OOC C (CH 2 ) 2 C N C C N CH 2 COO
2 NH 3 H CH 2 H
O 2 H O 2 SH 2 Glutathione
2 2
2 (GSH)
Hydroxy e 2H Oxidation Reduction
radical c

H O H O
2
OH O O H O OOC C (CH 2 ) 2 C N C C N CH 2 COO
2
NH 3 H CH 2 H
d Water
H 2H S Glutathione
disulfide (GSSG)
S
e
NH 3 H CH 2 H
OOC C (CH ) C N C C N CH 2 COO
2 2
1 Superoxide dismutase 2 Catalase H O H O
1.15.1.1 1.11.1.6 2. Glutathione

C. Erythrocyte metabolism

Glutathione reductase Methemoglobin Glutathione peroxidase
3 4 5
[FAD] 1.6.4.2 reductase [Se] 1.11.1.9/12

Glucose 6-
Glucose phosphate Pentose phosphate pathway

Glucose
N A N A N A N A
P P P P
Glycolysis
A
PP 3 3
3 Na
P
2 K 2 GSH GSSG 2 GSH GSSG
Na /K -
ATPase A PPP BPG 4 O 2 5

2 Lactate 2 3+ 2 2+ R-O-O-R' R -OH
2 Lactate R'-OH
Peroxide
Hb
Met-Hb

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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