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5  Optic disc and fovea detection  89

































                  FIG. 5
                  (A) Example of a gray scale image that is correlated with a (B) bright template that mimics
                  the OD. (C) The found OD candidates are marked as red plus signs. (D) The maximum
                  value of the vertical vessel information is highlighted in (E). The final OD location from the
                  two-step process is marked in (F).


                  showing the maximum response (maximum standard deviation) in the region of interest
                  is then found as the final OD location.
                     This method was tested on the Messidor dataset consisting of 1200 image, 400
                  each at different resolutions. The method was able to find the OD in 99.1% of the
                  images, based on ground truth boundary measurements. A correctly found OD was
                  considered anything inside the OD boundary area. Fig. 5 shows an example of the
                  processing steps involved, including the template matching to first find candidate OD
                  locations and then the analysis of vertical vessel information to determine the final
                  location.


                  5.5  Multiscale sequential convolutional neural networks for
                  simultaneous detection of the fovea and optic disc (Al-Bander
                  et al., 2018 [23])
                  The authors of this paper propose to use a deep convolutional neural network (CNN)
                  to detect both the OD and fovea. Over the past few years, deep learning has revo-
                  lutionized the field of machine learning, where deep networks have outperformed
                  tradition  machine  learning  techniques  across  a  wide  range  of fields.  Traditional
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