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182   Control theory in biomedical engineering


          6.3 A brief history
          In 1910, Theodor B€udingen proposed a patent for the first rehabilitation
          machine driven by an electric motor to guide and maintain stepping move-
          ments in patients with heart disease (Gassert and Dietz, 2018). In the 1930s,
          Richard Scherb developed a cable-driven apparatus to move joints for
          orthopedics therapy supporting multiple interaction modes (passive,
          active- and active-resisted movements). The first powered exoskeletons
          were proposed in the 1970s (Gassert and Dietz, 2018). The first robot
          deployed in clinical trials delivering rehabilitation therapy was the MIT-
          Manus developed in 1989, which uses a 6-DOF PUMA 560 robot to inter-
          act with the impaired patient. This system can operate in three unilateral
          modes and one bilateral mode (Krebs and Volpe, 2013). The unilateral
          modes are passive, in which the patient remains passive while the robot
          moves the arm along a preprogrammed path; active-assisted, in which the
          patient initiates movement and the robot assists and guides the motion along
          the desired path; and active-constrained, in which the robot resists motion
          along the path and provides a restoring force in all other directions. The Mir-
          ror Image Motion Enabler (MIME) was the first system to explore bilateral
          training in robotic applications for stroke rehabilitation (Burgar et al., 2000).
             Development of rehabilitation robots for the lower extremitis began in
          1994, with the design of the Lokomat (Gassert and Dietz, 2018). The most
          widely commercially available robotic systems for assisting individuals with
          disabilities are the Handy 1 (Rehab Robotics Limited, UK) developed in
          1987 by Mike Topping, which enables people with little or no hand func-
          tion to independently complete everyday functions such as eating, drinking,
          washing, shaving, and teeth cleaning (Topping and Smith, 1998); the
          wheelchair-mounted MANUS (Exact Dynamics, Netherlands) with two-
          fingered gripper (Driessen et al., 2001); and the wheelchair-mounted
          Raptor (Applied Resources Corporation, U.S.A.) that allows individuals
          with disabilities to feed themselves and reach objects on the floor, on a table,
          or above their heads (Speich and Rosen, 2008).


          6.4 Classification and related devices
          Rehabilitation robots can be classified and studied using various taxo-
          nomies. The most natural classification is based on the anatomy of the
          two extremities of the human body (Hesse et al., 2003; Pitkin, 2015) by con-
          sidering upper extremity rehabilitation devices (Butcher and Meals, 2002;
          Balasubramanian et al., 2010; Brochard et al., 2010; Gopura et al., 2011;
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