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Fundamentals of Experimental Design  441


           than low-order interactions. However, a higher-resolution design for
           the same number of factors will require more runs. In two-level frac-
           tional factorial experiments, the following three resolutions are most
           frequently used:

             Resolution III designs. Main effects are confounded (aliased) with
             two-factor interactions.
             Resolution IV designs. No main effects are aliased with two-factor
             interactions, but two-factor interactions are aliased with each other.
             Resolution V  designs. No main effects or two-factor interaction is
             aliased with any other main effects or two-factor interaction, but
             two-factor interactions are aliased with three-factor interactions.

                              k
           12.4.4  1 ⁄4 fraction of 2 design
           When the number of factors k increases, 2 k   1  will also require many
           runs. Then, a smaller fraction of factorial design is needed. A  ⁄4 frac-
                                                                      1
           tion of factorial design is also called a 2 k   2  design.
             For a 2 k   1  design, there is one defining relationship, and each defining
           relationship is able to reduce the number of runs by half. For a 2 k   2
           design, two defining relationships are needed. If one P and one Q repre-
           sent the generators chosen, then I   P and I   Q are called generating
           relations for the design. Also, because I   P and I   Q, it follows that
           I   PQ. I   P   Q   PQ is called the complete defining relation.

           The 2 6   2  design. In this design, there are six factors, say, A, B, C, D, E,
           and F. For a 2 6   1  design, the generator would be I   ABCDEF, and
           we would have a resolution VI design. For a 2 6   2  design, if we choose
           P and Q to have five letters, for example, P   ABCDE, Q   ACDEF,
           then PQ   BF, from I   P   Q   PQ, in the complete defining relation,
           I   ABCDE   ACDEF   BF, we will have only resolution II! In this
           case even the main effects are confounded, so clearly it is not good. If
           we choose P and Q to be four letters, for example, P   ABCE, Q
           BCDF, then PQ   ADEF, and I   ABCE   BCDF   ADEF, this is a
           resolution IV design. Clearly, it is also the highest resolution that a
           2 6   2  design can achieve.
             We can now develop a procedure to lay out 2 k   2  design, outlined in
           the following steps:

             Step 1: Compute N   2 k   2  and determine the number of runs. For the
             2 6   2  example, for k   6, N   2 k   2    2 4   16.
             Step 2: Create a table with N runs and lay out the first k   2 factors
             in standard order. For example, for k   6, the factors are A,B,C,D,E,F.
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