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Section 4.8  Design  Examples                                       261
                        Control  Goal
                            Regulate  the  mean  arterial  pressure  to  any desired  set-point  and  maintain  the
                            prescribed  set-point  in the presence  of unwanted  disturbances.
                        Associated  with the stated  control goal, we identify  the variable to be  controlled:

                        Variable to Be  Controlled
                            Mean  arterial pressure  (MAP).

                        Because  it  is  our  desire  to  develop  a  system  that  will  be  used  in  clinical  appli-
                        cations, it  is essential  to  establish  realistic  design  specifications.  In  general  terms
                        the  control  system  should  have  minimal  complexity  while  satisfying  the  control
                        specifications. Minimal complexity  translates into increased  system reliability  and
                        decreased  cost.
                            The closed-loop system should respond  rapidly and  smoothly to changes in the
                        MAP set-point  (made  by the  anesthetist)  without  excessive overshoot. The  closed-
                        loop  system  should  minimize  the  effects  of  unwanted  disturbances. There  are  two
                        important  categories  of  disturbances:  surgical  disturbances,  such  as  skin  incisions
                        and measurement errors, such as calibration errors and random  stochastic noise. For
                        example,  a  skin  incision  can  increase  the  MAP  rapidly  by  10 mmHg  [26]. Finally,
                        since we want  to  apply  the  same control  system  to many  different  patients  and  we
                        cannot  (for practical reasons) have  a separate model for each patient, we must  have
                        a closed-loop system that is insensitive to changes in the process parameters (that is,
                        it meets the specifications  for  many different  people).
                            Based  on  clinical experience  [24], we  can  explicitly  state  the  control  specifica-
                        tions as follows:
                        Control Design  Specifications
                           DS1  Settling time less than 20 minutes for a 10% step change from  the MAP set-point.
                           DS2  Percent overshoot less than  15% for a 10% step change from  the MAP set-point.
                           DS3  Zero steady-state tracking error to a step change from  the MAP set-point.
                           DS4  Zero steady-state error to a step surgical disturbance input (of magnitude
                                \d(t)\  ^  50) with a maximum response less than ±5%  of the MAP set-point.
                           DS5  Minimum sensitivity to process parameter changes.
                        We cover the notion  of percent overshoot  (DS1) and settling time (DS2) more  thor-
                        oughly  in  Chapter  5. They  fall  more  naturally  in  the  category  of  system  perfor-
                        mance. The  remaining  three  design  specifications, DS3-DS5, covering  steady-state
                        tracking  errors  (DS3), disturbance  rejection  (DS4), and  system  sensitivity to  para-
                        meter changes (DS5) are the main topics  of this chapter. The last specification, DS5,
                        is somewhat  vague; however,  this  is  a  characteristic  of  many  real-world  specifica-
                        tions.  In  the  system  configuration,  Figure  4.24, we  identify  the  major  system  ele-
                        ments as the controller, anesthesia pump/vaporizer, sensor, and  patient.
                            The system input  R(s)  is the desired mean arterial pressure change, and the  out-
                        put  Y(s)  is the  actual  pressure  change. The  difference  between  the desired  and  the
                        measured  blood pressure  change  forms  a signal used  by the controller to  determine
                        value  settings  to  the  pump/vaporizer  that  delivers  anesthesia  vapor  to  the  patient.
                            The  model  of  the  pump/vaporizer  depends  directly  on  the  mechanical  design.
                        We  will  assume  a  simple  pump/vaporizer,  where  the  rate  of  change  of  the  output
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