Page 574 - Book Hosokawa Nanoparticle Technology Handbook

APPLICATIONS 30 NOZZLE-FREE INKJET TECHNOLOGY

Administration route
6 Modifier Carotid artery Jugular vein
Particle concentration in the brain (% /g tissue) 4 2 Polysorbate 80

Non

Poloxamer 188
Chitosan

0
0 60 120 180 240
Time (min)

Figure 29.3
Effect of administration route on the brain distribution of surface-modified poly(DL-lactic-co-glycolic acid) nanoparticles.

3. Perspective of brain targeting with nanoparticles References
Investigations on brain function are progressing [1] J. Kreuter: Adv. Drug Deliv. Rev., 47, 65–81 (2001).
extensively from physiological, organizational and [2] C. Vautier, C. Dubernet, E. Fattal, H. Pinto-Alphandary,
cytological viewpoints. Therapy against the brain
and CNS diseases is becoming more and more P. Couvreur: Adv. Drug Deliv. Rev., 55, 519–548 (2003).
important. By elucidating the function of brain and [3] P.R. Lockman, M. Oyewumi, J. Koziara, K. Roder,
the mechanism of brain diseases clearly, the drug R. Mumper, D. Allen: J. Control Release 93, 271–282
delivery system with nanoparticles can be designed (2003).
more precisely to cure currently incurable diseases [4] P. Calvo, B. Gouritin, H. Chacun, D. Desmaele,
of brain and CNS. J. D’Angelo, JP. Noel, D. Georgein, E. Fattal,
JP. Andreux, P. Couvreur: Pharm. Res., 18, 1157–1166
(2001).
APPLICATION 30

30 NOZZLE-FREE INKJET TECHNOLOGY

Inkjet technology was developed as a new printing due to the deformation of the piezoelectric device in
method and due to the rapid proliferation of the com- the piezoelectric method, and due to the pressure of an
puter, it has been widely used in low-cost, small-sized air bubble created inside the ink by heating in the
printing units such as printers or copying machines thermal or the bubble-jet method. Therefore, the ink
for domestic use. The inkjet printing method is classi- needs to have properties suitable for the nozzle such
fied into two categories. One method uses a piezo- as high fluidity, low viscosity, and appropriate drying
electric device that gets deformed when a voltage is property, and a cleaning system is always provided for
applied to it. The other is the thermal or the bubble jet clearing clogged ink. In addition, this inkjet technol-
method that utilizes the generation of air bubbles due ogy is not merely used in printing machines but is also
to heating. Both methods require very fine nozzles. being used for the manufacture of devices such as
The ink is pushed out from the nozzle for the printing multilayer printed circuit boards, displays, or DNA

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